Initiation, Labile, and Stabilization Phases of Experience-Dependent Plasticity at Neocortical Synapses
نویسندگان
چکیده
منابع مشابه
Initiation, labile, and stabilization phases of experience-dependent plasticity at neocortical synapses.
Alteration of sensory input can change the strength of neocortical synapses. Selective activation of a subset of whiskers is sufficient to potentiate layer 4-layer 2/3 excitatory synapses in the mouse somatosensory (barrel) cortex, a process that is NMDAR dependent. By analyzing the time course of sensory-induced synaptic change, we have identified three distinct phases for synaptic strengtheni...
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Early Development of Glutamatergic Synaptic Currents The majority of fast excitatory neurotransmission in the CNS is mediated by ionotropic glutamate receptors, which are divided into NMDA, AMPA, and kainate receptor subtypes on the basis of the biophysical properties of their currents, their sensitivity to different pharmaco-Glutamatergic synaptic currents undergo a characteris-logical agents,...
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Sensory experience can selectively alter excitatory synaptic strength at neocortical synapses. The rapid increase in synaptic strength induced by selective whisker stimulation (single-row experience/SRE, where all but one row of whiskers has been removed from the mouse face) is due, at least in part, to the trafficking of AMPA receptors (AMPARs) to the post-synaptic membrane, and is development...
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Corticostriatal projections originate from the entire cerebral cortex and provide the major source of glutamatergic inputs to the basal ganglia. Despite the importance of corticostriatal connections in sensorimotor learning and cognitive functions, plasticity forms at these synapses remain strongly debated. Using a corticostriatal slice preserving the connections between the somatosensory corte...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3575-12.2013